4 小结

运动作为一种应激手段能够提高对骨骼肌、肝脏等器官对IGF- I 的分泌, 进而促使骨骼肌细胞增殖和分化^{[7, 22]} , 增加蛋白质的合成, 抑制蛋白质的降解^[23] 。低氧运动对GH- IGF- I 功能轴距有抑制作用。低氧训练( 高原训练) 对体重、体成份都产生了一定的影响。这与IGF- I、GH 以及睾酮、皮质醇等其他激素或因素有关系。具体的作用机制需要进一步研究。近年来大多报道的是血液中IGF- I 与运动、低氧运动的关系, 对骨骼肌中IGF- I 的影响尚未见报道。

参考文献:

[1] 魏俊辉.类胰岛素生长因子结合蛋白[J].国外医学(内分泌学分册),1994,14 (4):175- 177.

[2] 曾凡星.人类胰岛素样生长因子- I 的研究进展[J].北京体育大学学报,1998,(21)3.

[3] 李云霞, 陈世益.胰岛素样生长因子促进骨骼肌损伤修复[J].上海体育科研,2003 ,24 (1):33- 39.

[4] Rinderkneeht E,Hmbel R E. Primary structure of human IGF - 2[J]. FEBS Lett, 1978, 89: 283 – 286.

[5] Lo HC,Hirvonen MD,Knitsch KR,et al.Growth hormoneor insulin-like growth factor- Ⅰincreases fat oxidation and decreasesprotein oxidation without altering energy expenditure in parenterallyfed rats[J ]. AmJ Clin Nutr, 1997, 65 (11):1384- 1390.

[6]Kerr D E. Effects of passive immunization of growing guinea - pigswith an IGF- I monoclonal antibody [J].J Endocrinol,1990,24: 403–415.

[7] Devol D L.Activation of IGF- I gene expression during work- inducedskeletal muscle growth [J].Am J Physiol,1990 ,259 :89 –95.

[8] Eden J A, et al.1988 Does serum IGF - I have an endocrine rolein the control of follicular function? [J].Endocrinol,119(Sup2pl),Abstract.No.163.

[9] Duan C, Plisetskaya EM. Nutritional regulation of IGF- ImRNAexpression in salmon tissues[J].Endocrino,1993,139: 243 - 252.

[10] Russell SM,Speneer EM. Local indentions of human or rat growthhormone of purified human somatomed in - C stimulate unilateraltibial epiphyseal growth in hypophysectomized rats [J].Endocrinology,1987,116: 2563- 2567.

[11] SkottnerA.Recombinant human IGF- I: testing the somatomed inhypothesis in hypophysectorized rats [J].Endocrinol,1987,112:123- 132.

[12] 魏俊辉.类胰岛素生长因子结合蛋白[J].国外医学内分泌学分册,1994 ,14 (4) :175- 177.

[13] 廖二元.内分泌学(上、下) [M].北京:人民卫生出版社,2003 .

[14] Brink M,Chrast J, Price SR,et al. Angiotens in Ⅱ stimulatesgene expresssion of cardiac insulin2like growth factor Ⅰ and itsreceptor through effects on blood pressure and food intake [J].Hypertension,1999,34 (5):1053- 1059.

[15] 陆耀飞.短期不同类型跑台训练对大鼠骨骼肌IGF- I 基因表达的影响[J].上海体育学院学报, 2007,(27):5.

[16] Kramer WJ. Response of IGF- Ⅰ to endogenous increase ingrowth hormone after heave resistance exercise [J].J Appl Physiol, 1995,79 :13- 15.

[17] 徐国营,刘迅雷.运动对大鼠骨骼肌及血清GH,IGF- I 水平研究[J].西北大学学报(自然科学版),2002,(5)5:136- 138.

[18] Nicklas BJ.Testosterone,growth hormone and IGF2I responses toacute and chronic resistive exercise in men aged 55270 years [J].Into J Sports Med,1995,(16) :44- 51.

[19] ADAMS G. R, HADDAD F.The relationship s among IGF- I,DNA content, and protein accumulat ion during skeletal musclehypert rophy[J].Appl Physiol,1996,81: 2509- 2516.

[20] Gutierrez A. Acute exposure to moderate high altitude decreasesgrowth hormone response to physical exercise in untrained subjects[J]. Journal of Sports Medicine & Physical Fitness,2003,43(4):554- 558.

[21] Schmidt.W. Effects of exercise during normoxia and hypoxiaon the growth hormone insulin- like growth factor I axis [J].Eur JAppl Physiol Occup Physiol,1995,71 (5) :424- 430.

[22] ZANCONA TO S, DAV ID Y M.Effect of training and growthhormone suppression on insulin- like growth factor ImRNA inyoung rat [J].Appl Physiol,1994,76: 2204- 2209.

[23] Adams GR,Samuel A.Localized infusion of IGF- I results inskeletal muscle hypertrophy in rats [J].J Appl Physiol,1998,(84):1716- 1722.