6 问题与展望
酒精性骨质疏松症(AOP) 的确切发病机制目前仍未完全清楚,有许多问题有待深入研究和探讨: ①酒精直接作用于骨骼系统,还是与其活体内特定的代谢产物如:乙醛、硫酸乙酯等共同作用以及具体分子生物学途径有待进一步研究[34 ] 。②目前细胞学实验研究主要集中在酒精对骨髓间充质干细胞诱导分化,干扰成骨细胞、破骨细胞增殖、活性等方面,其具体分子生物学作用途径还不清楚,还需深入研究探讨。③人类基因多态性与酒精性骨质疏松的发病有着密切的关系,也是非常值得研究的重要课题之一。④理想的动物模型建立,适量饮酒与骨骼的关系将是值得我们深入探讨的课题。⑤酒精对细胞因子及生长因子的影响与酒精性骨质疏松的发病亦有密切关系,也有待进一步深入研究。总之,酒精性骨质疏松症(AOP) 需要进一步深入研究,而从中西医结合的角度研究将是一个新的研究方向和发展趋势。
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