骨代谢与铁代谢相关研究进展

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4　结　语

对骨代谢的研究是一项长期而艰巨的任务,随着对骨代谢与铁代谢研究的进一步深入,以及铁调素对铁代谢调节作用研究的深入,可循铁调素-膜铁转运蛋白2铁代谢2骨代谢的循环过程, 通过研究HJV、炎症、缺氧和贫血等对铁调素表达的调节,铁调素对铁代谢的调节以及铁代谢与骨代谢的相关性来研究人体的骨代谢,从而为解决骨质矿化异常的研究开辟出一条新的思路。

参考文献
[ 1 ] 　Liu G,Men P, Kenner GH, et al. Age2associated iron accumulation in bone: imp lications for postmenopausal osteoporosis and a new target for p revention and treatment by chelation [ J ]. Biometals,2006, 19 (3) : 2452251.
[ 2 ] 　Cornish J, Palmano K, Callon KE, et al. Lactoferrin and bone;structure2activity relationship s [ J ]. Biochem Cell Biol, 2006, 84(3) : 2972302.
[ 3 ] 　Houtkooper LB, Stanford VA,Metcalfe LL, et al. Preventing osteoporosis the bone estrogen strength training way[ J ]. ACSMs Health Fitness J, 2007, 11 (1) : 21227.
[ 4 ] 　Krause A,Neitz S,Magert HJ, et al. LEAP21, a novel highly disulfide2bonded human pep tide, exhibits antimicrobial activity [ J ].FEBS Lett, 2000, 480 (2 /3) : 1472150.
[ 5 ] 　Park CH,Valore EV,Waring AJ, et al. Hepcidin, a urinary antimicrobial pep tide synthesized in the liver[ J ]. J Biol Chem, 2001, 276(11) : 780627810.
[ 6 ] 　Rivera S, Liu L,Nemeth E, et al. Hepcidin excess induces the sequestration of iron and exacerbates tumor2associated anemia [ J ].Blood, 2005, 105 (4) : 179721802.
[ 7 ] 　Papanikolaou G, TzilianosM, Christakis J I, et al. Hepcidin in iron overload disorders[ J ]. Blood, 2005, 105 (10) : 410324105.
[ 8 ] 　Ganz T. Molecular pathogenesis of anemia of chronic disease [ J ].Pediatr Blood Cancer, 2006, 46 (5) : 5542557.
[ 9 ] 　Donovan A,Lima CA, Pinkus JL, et al. The iron exporter ferroportin /Slc40a1 is essential for iron homeostasis[ J ]. CellMetab, 2005,1 (3) : 1912200.
[ 10 ] 　Papanikolaou G, Samuels ME, Ludwig EH, et al. Mutations in HFE2 cause iron overload in chromosome 1q2linked juvenile hemo chromatosis[ J ]. Nat Genet, 2004, 36 (1) : 77282.
[ 11 ] 　Brinks H, Conrad S,Vogt J, et al. The repulsive guidance molecule RGMa is involved in the formation of afferent connections in the dentate gyrus[ J ]. J Neurosci, 2004, 24 (15) : 386223869.
[ 12 ] 　Matsunaga E, Chédotal A. Repulsive guidance molecule /neogenin:a novel ligand2recep tor system p layingmultip le roles in neural development[ J ]. Dev Growth Differ, 2004, 46 (6) : 4812486.
[ 13 ] 　NiederkoflerV, Salie R, SigristM, et al. Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system [ J ]. J Neurosci,2004, 24 (4) : 8082818.
[ 14 ] 　Samad TA, Srinivasan A, Karchewski LA, et al. DRAGON: a member of the repulsive guidance molecule2related family of neuronal and muscle2exp ressed membrane p roteins is regulated by DRG11 and has neuronal adhesive p roperties [ J ]. J Neurosci, 2004, 24(8) : 202722036.
[ 15 ] 　Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell2associated hemojuvelin [ J ]. Blood,2005, 106 (8) : 288422889.
[ 16 ] 　ZhangAS,WestAP J r,Wyman AE, et al. Interaction of hemojuvel in with neogenin results in iron accumulation in human embryonic kidney 293 cells[ J ]. J Biol Chem, 2005, 280 (40) : 33885233894.
[ 17 ] 　Ganz T,Nemeth E. Regulation of iron acquisition and iron distribution in mammals[ J ]. Biochim BiophysActa, 2006, 1763 (7) : 690.
[ 18 ] 　Rajagopalan S,DeitinghoffL,DavisD, et al. Neogenin mediates the action of repulsive guidance molecule [ J ]. Nat Cell Biol, 2004, 6(8) : 7562762.
[ 19 ] 　Wang RH,Li C, Xu X, et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin exp ression [ J ]. CellMetab, 2005, 2 (6) : 3992409.