综上所述,由于目前对丙型肝炎的治疗尚缺乏有效手段,因此发展治疗性疫苗对控制HCV感染极为重要。目前,很快研制出有效治疗HCV感染的疫苗并不现实。但随着对HCV蛋白和序列作用的不断认识及新研究靶点的不断出现,必将设计出包含有多个保守HCV抗原表位的多价融合抗原基因的DNA疫苗。该疫苗可以在人群的不同个体中激起广泛而强烈的对不同HCV基因型和分离株有交叉反应性的T细胞免疫应答,并有望应用于HCV感染人群的治疗。
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来源:医学综述 作者:陈佳玉