生物型cage 在脊柱融合中应用的研究进展

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6 生物型cage 应用的研究展望

生物型cage 的应用为深入研究脊柱融合带来了契机, 其涉及生物材料学、脊柱解剖学、生物力学、计算机有限元分析等诸多领域。

cage的功能在于恢复或维持椎间高度及提供椎间的即刻稳定以促进椎间融合, 应优化设计与构筑新型cage的结构特性与功能特征, 包括连接良好的内在显微孔性结构、附载生长因子及承受应力的皮质骨样外在结构。计算机辅助设计、数字化三维CT, 显微CT 分析(Micro- CT) 等新兴技术能通过对宿主解剖部位图像重建及数据分析, 量体裁衣研制出符合个体化生理需求的新型生物cage。

有学者证实运载富血小板血浆( platelet- rich plasma,PRP) 及生物陶瓷的碳纤维cage 能提高融合程度^[24]。随着干细胞移植、基因治疗及脊柱内窥镜微创术式的应用, 生物型cage 能否与它们有机结合, 以促进脊柱融合, 将是今后需要探索与努力的方向。

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