【参考文献】
[ 1 ] Mundy G,Garrett R ,Harris S ,et al . Stimulation of bone formation invitro and in rodents by statins. Science , 1999 , 286 :194621949.
[ 2 ] Sugiyama M, Kodama T , Konishi K, et al . Compactin andsimvastatin , but not pravastatin , induce bone morphogenetic protein22in human osteosarcoma cells. Biochem Biophys Res Commun , 2000 ,271 :6882692.
[ 3 ] Bai Y, Zhang L , Lv ZW, et al . The effect of simvastatin on theosteoblastic differentiation of human bone marrow stromal cells. Chin__ J Osteoporos , 2006 ,13(6) :3812384(in Chinese) .
[ 4 ] Cai J , Zhang L , YU XQ , et al . Simvastatin promotes osteoblasticdifferentiation of human bone marrow stromal cells. Chin JOsteoporos , 2006 ,12(4) :3972400(in Chinese) .
[ 5 ] Yu XQ , Zhang L ,Cai J , et al . Effects of simvastatin on Cbfal ,Cbfband Osterix expressions in human bone marrow stromal cells. J FourthMilMed Univ , 2006 ,27 (23) :217522178(in Chinese) .
[ 6 ] Wilkie D ,Bowman B ,Lyga A , et al . Cerivastatin increases corticalbone formation in OVX rats. J Bone Miner Res ,2000 ,15 :S549.
[ 7 ] Oxlund H ,dalstra M,Andreassen TT , et al . Statin given perorally toadult rats incteases cancellous bone mass and compressive strength.Calcif Tissue Int ,2001 ,69 :2992304.
[ 8 ] Skoglund B , Forslund C , Aspenberg P. Simvastatin improvesfracturehealing in mice. J Bone Miner Res ,2002 ,17 :200422008.
[ 9 ] Serin Kilicoglu S , Erdemli E. New addition to the statinps effect . JTrauma , 2007 ,63 :1872191.
[10 ] Saraf SK, Singh A , Garbyal RS , et al . Effect of simvastatin onfracture healing ———an experimental study. Indian J Exp Biol ,2007 ,45(5) :4442449.
[11 ] Adah F , Benghuzzi H , Tucci M, et al . Cholesterol productioninhibitor (statin) increased bone healing in surgically created femoraldefect in an animal model . Biomed Sci Instrum,2007 ,43 :952103.
[12 ] Skoglund B , Aspenberg P. Locally applied Simvastatin improvesfracture healing in mice. BMC Musculoskelet Disord ,2007 , 8 :98.
[13 ] Zheng J , Zhang L , Yao SS , et al . Stimulation on osteoblasticdifferentiation in bone marrow stromal cells of rats by simvastatinadministration. Chin J Osteoporos , 2006 , 12 ( 3 ) : 2782282 ( inChinese) .
[14 ] Yao SS , Zhang L , Zheng J , et al . Effect of simvastatin onosteoblastic differentiation of bone marrow stromal cells in rats. JFourth MilMed Univ , 2006 ,27 (17) :160921612(in Chinese) .
[15 ] Ye WS , YU SL , Wang BT , et al . Stimulation of bone formation inovariectomized rat by intermittent administration of simvastatin. ChinJ Osteoporos , 2001 ,21(7) :4282432(in Chinese) .
[16 ] YU SL , Ye WS , Kong DC , et al . Effects of statins andbiophosphonates on femur of ovariectomized rats. Chin J Osteoporos ,2002 ,8 (3) :2432247(in Chinese) .
[17 ] Liang CY, Zhang L , Zhao WG, et al . Effects of simvastatin femoralfracture healing in rats. J Fourth MilMed Univ , 2006 ,27 (3) :2842286(in Chinese) .
[18 ] Zhang L , Liu F , Liang CY, et al . Effects of simvastatin femoralfracture healing in ovariectomized rats. J Fourth MilMed Univ , 2007 ,28(15) :137221375(in Chinese) .
[19 ] Maritz FJ , Conradie MM, Hulley PA , et al . Effect of statins on bonemineral density and bone histomorphometry in rodents. ArteriosclerThromb Vasc Biol , 2001 , 21 : 163621641.
[20 ] Hughes A , Rogers MJ , Idris AI , et al . A comparison between theeffects of hydrophobic and hydrophilic statins on osteoclast function invitro and ovariectomy2induced bone loss in vivo. Calcif Tissue Int ,2007 , 81 :4032413.
[21 ] Von Stechow D , Fish S , Yahalom D , et al . Does simvastatinstimulate bone formation in vivo ?BMC Musculoskeled Disord ,2003 ,4 :8.
[22 ] Tian FM, Zhang L , Meng YQ , et al . Effects of simvastatin on bonemass and the proliferation and differentiation of bone marrow stromalcells in rats. Chin J Osteoporos , 2007 , (13) :5802584(in Chinese) .
[23 ] Schoofs MW. Sturkenboom MC , van der K1ift M, et al . HMG2CoAreductase inhibitors and the risk of vertebral fracture. J Bone MinerRes ,2004 ,19 :152521530.
[24 ] Rejnmark L ,Olsen ML ,Johnsen SP ,et al . Hip fracture risk in statinusers2a population2based Danish case2control study. Osteoporos Int ,2004 ,15 :4522458.
[25 ] Lupattelli G,Scarponi AM,Vaudo G,et al . Simvastatin increases bonemineral density in hypercholesterolemic postmenopausal women. Me2tabolism,2004 ,53 :7442748.
[26 ] Bauer DC , Sklarin PM, Stone KL , et al . Biochemical markers ofbone turnover and prediction of hip bone loss in older women : thestudy of osteoporotic fractures. J Bone Miner Res ,1999 , 14 : 140421410.
[27 ] Wang PS , Solomon DH , Mogun H , et al . HMG2CoA reductaseinhibitors and the risk of hip fractures in elderly patients. JAMA ,2000 , 283 : 321123216.
[28 ] Meier CR , Schlienger RG,Kraenzlin ME , et al . HMG2CoA reductaseinhibitors and the risk of fractures. JAMA ,2000 , 83 : 320523210.
[29 ] Ray WA ,Daugherty JR , Griffin MR. Lipid2lowering agents and therisk of hip fracture in amedicaid population. Inj Preve ,2002 ,8 (4) :2762279.
[30 ] Van Staa TP ,Wegman S ,de Vres F ,et al . Use of statins and risk offractures. JAMA ,2001 ,285 :185021855.
[31 ] Hatzigeorgiou C , Jackson JL. Hydroxymethylglutaryl2coenzyme Areduc2tase inhibitors and osteoporosis : a meta2analysis. OsteoporosInt ,2005 ,16 :9902998.
[32 ] Solomon DH , Finhelstein JS ,Wang PS , et al . Statin lipid2loweringdrugs and bone mi neral density. Pharmacoepidemiol Drug Saf ,2005 ,14 :2192226.
[33 ] Montngnani A , Gonnelli S , Cepollaro C , et al . Effect of simvastatintreatment on bone mineral density and bone turnover inhypereholesterolemic postmenopausal women : a 12year longitudinalstudy.Bone ,2003 ,32 :4272433.
[34 ] Tikiz C ,Unlu Z , Tikiz H , et al . The effect of simvsatatin on serumcytokine levels and bone metabolism in postmenopausal subjects :negative correlation between TNF2alpha and anabolic boneparameters. J Bone Miner Metab ,2004 ,22 :3652371.
[35 ] Pasco JA , Kotowicz MA , Henry MJ , et al . Statin use , bone mineraldesity, and fracture risk : Geelong Osteoporosis Study. Arch InternMed , 2002 ,162 :5372540.
