参考文献

[ 1 ] Sayegh MH ,Carpenter CB. Transplantation 50 Years Later2Pro2gress ,Challenges and Promises[J ] . N Engl J Med ,2004 ,351 (26) :2761 - 2766.

[ 2 ]昌　盛,沈世乾,陈必成,等. 探讨抗γ公共链单抗诱导移植物免疫耐受的作用机制[J ] . 中华器官移植杂志,2005 ,26 (8) : 470 -473.

[ 3 ]Broxmeyer HE ,LuL ,Cooper S ,et al . F1t3 ligand stimulates/ cos2timulates t he growt h of myeloid stem/ progenitor cells [ J ] . ExpHemato1 ,1995 ,23 (10) :1121 - 1129.

[ 4 ]Ohata J ,Sakurai J ,Saito K,et al . Differential graft2versus2leukae2mia effect by CD28 and CD40 co2stimulatory blockade after graft2versus - host disease prophylaxis [ J ] . Clin Exp Immunol , 2002 ,129 (1) :61 - 68.

[ 5 ]Opelz G,Sengar DP ,Micrey MR ,et al . Effect of blood t ransfusionson subsequent kidney t rarmplant s [ J ] . Transplantation Proc ,1973 ,5 (1) :253 - 259.

[ 6 ]Bayle F ,Masson D , Zaoui P ,et al . Beneficial effect of one HLAhaplo - or semi2identical t ransfusion versus t hree untyped bloodunit s on alloimmunization and acute rejection eposodes in first re2 nal allograft recipient s [ J ] . Transplantation , 1995 , 59 ( 5) : 719 -723.

[ 7 ] Guo C ,Dai K, Tang T. In vit ro study of immune tolerance inducedby CTLA42Ig in bone t ransplantation : The effect on cell prolifer2ation stimulated by lymphocytes and bone supernatant [ J ] . J Or2t hop Surg ,2000 ,8 (1) :79 - 82.

[ 8 ]Blancho G, Gianello PR ,Lorf T , et al . Molecular and cellular e2vent s implicated in local tolerance to kidney allograft s in minia2tures wine[J ] . Transplantation ,1997 ,63 (1) :26 - 33.

[9 ] Kita Y,Li XK,0hba M ,et al . Prolonged cardiac allograft survivalin rat s systemically injected adenoviral vectors containing CT2LA4Ig2gene[J ] . Transplantation ,1999 ,68 (6) :758 - 766.

[10 ]丁国善,王全兴,张　明,等. CTLA24Ig 与ICAM21 单抗促进供者来源的未成熟树突状细胞诱导移植受体免疫耐受[J ] . 第二军医大学学报,2006 ,27 (2) :253 - 257.

[ 11 ] Parker DC ,Greiner DL ,Phillips NE ,et al . Survival of mouse pan2creatic islet allograft s in recipient s t rested wit h allogeneic smalllymphocytes and antibody to CD40 ligant [J ] . Proc Natl Acad SciUSA ,1995 ,92 (21) :9560 - 9564.

[ 12 ] Kirk AD ,J adaki DK,Celniker A , et al . Induction t herapy wit hmonoelonal antibodies specific for CD80 and CD86 delays t he on2set acute rens〗allograft rejection in non2human primates [ J ] .Transplantation ,2001 ,72 (3) :377 - 379.

[13 ] Kirk AD ,Blair PJ , Tadaki DK,et al . The role of CD154 in organt ransplant rejection and acceptance[J ] . Philos Trans R Soc LondB Biol Sci ,2001 ,356 :691 - 702.

[ 14 ]张　峰,吕　凌,浦立勇,等. CD4 + CD25 + Tr 细胞与大鼠肝移植自发免疫耐受关系的研究[ J ] . 中华外科杂志, 2006 , 44 ( 21) :1463 - 1466.

[ 15 ] Ermann J ,Szanya V , Ford GS ,et al . CD4 ( + ) CD25 ( + ) T cell sfacilitate t he induction of T cell anergy[J ] . J Immunol ,2001 ,167(8) :4271 - 4275.

[ 16 ]Malek TR ,Yu A ,Vincek V , et al . CD4 regulatory T cells pre2vent let hal autoimmunity in IL22Rbeta2deficient mice. Implica2tions for t he nonredundant function of IL22[J ] . Immunity ,2002 ,17 (2) :l67 - 178.

[ 17 ]Almeida AR ,Legrand N ,Papiernik M ,et al . Homeostasis of pe2ripheral CD4 + T cells : IL22R alpha and IL22 shape a populationof regulatory cells t hat cont rol s CD4 + T cell numbers [J ] . J Im2munol ,2002 ,169 (9) :4850 - 4860.

[ 18 ]Wolf M ,Schimpl A , Hunig T. Cont rol of T cell hyperactivationin IL222deficient mice by CD4 ( + ) CD25 ( - ) and CD4 ( + ) CD25( + ) T cells : evidence for two distinct regulatory mechanisms[J ] . Eur J lmmunol ,2001 ,3l (6) :1637 - 1645.

[ 19 ] Taams IS ,Vukmanovic2Stejic M ,Smit h J ,et al . Antigen - specificT cell suppression by human CD4 + CD25 + regulatory T cels[J ] .Eur J Immunol ,2002 ,32 :l621 - 1630.

[ 20 ]Otto C ,Kauczok J ,Martens N ,et al . Mechanisms of tolerance in2duction after rat liver t ransplantation : int rahepatic CD4 ( + ) Tcels produce difierent cytokines during rejection and tolerance inresponse to stimulation [ J ] . J Gast rointest Surg ,2002 , 6 : 455 -463.

[ 21 ] Sakaguchi S. Naturally arising CD4 + regulatory T cells for im2munologic self2tolerance and negative cont rol of immune respon2ses[J ] . Ann Rev Immuno1 ,2004 ,22 :531 - 562.

[ 22 ]Asakura H ,Ku G,Kataoka M ,et al . Regulatory cels develop af2ter t he spontaneous acceptance of rat liver allograt s[J ] . Surgery ,2004 ,136 :532 - 536.

[ 23 ]Link H ,Xiao BG. Rat models as tool to develop new immuno2t herapies[J ] . Immunol Rev ,2001 ,184 :117 - 128.

[ 24 ]Oluwole SF ,Chowdhury NC ,Fawwar RA ,et al . Induction of do2norspecific unresponsiveness to rat cardiac allograft s by ret reat2ment wit h int rat hymic donor MHC class 1 antigens [ J ] . Trans2plantation ,1993 ,55 (6) :1389 - 1394.

[ 25 ]De Smedt T ,Van Meehelen M ,De Becker G,et al . Effect of in2terleukin210 on dendriticcell maturation and function [ J ] . Eur JlmmunO1 ,1997 ,27 :1229 - 1235.

[ 26 ] Sehwarze ML ,Menard MT , Fuchimoto Y,et al . Mixed hemato2poietic chimerism induces long2term tolerance to cardiac al2lograft s in miniature swine[J ] . Ann t horac Surg ,2000 ,70 :131 -138.

[ 27 ] Knechtle SJ ,Fechner J r J H ,Dong Y, et al . Primate renal t rans2plant s using immunotoxin[J ] . Surgery ,1998 ,124 (2) :438 - 446.

[ 28 ] Knechtle SJ , Pirsch JD , Fechner H ,et al . Campat h2l H inductionplus rapamycin monot herapy for renal t ransplantation : result s ofa pilot study[J ] . Am J Transplant ,2003 ,3 :722 - 730.

[ 29 ]Levent hal J R ,Gallon L ,Kaufman DB ,et al . Alemtuzumab (Cam2pat h 1H) facilitates prednisone2f ree immunosuppression ( IP) inkidney t ransplant recipient s [J ] . Am J Transplant ,2003 ,3 ( suppl5) :310.

[ 30 ]Shapiro R ,Jordan ML ,Basu A ,et al . Kidney t ramplantation un2der a tolerogenic regimen of recipient pret reatment and low2doeepostoperative immunosuppression wit h subsequent weaning[J ] Ann Surg ,2003 ,238 :520 - 525.

[ 31 ]Wekerle T ,Sykes M. Mixed chimerism as an approach for t he in2duction of t ransplantation tolerance [ J ] . Translantation , 1999 ,68 :459 - 467.

[ 32 ]Spitzer TR , Delmonico F , Tolkoff2Rubin N et al . Combined his2tocompatibility leukocyte antigen2matched donor bone marrowand renal t ransplantation for multiple myeloma wit h end stagerenal disease : t he induction of allograft tolerance t hrough mixedlymphohematopoietic chimerism[ J ] . Transplantation , 1999 , 68 :480 - 484.

[ 33 ]Anderson CC ,Matzinger P. Immunity or tolerance : opposite out2comes of microchimerism f rom skin graft s [J ] . Nat Med ,2001 ,7(1) :80 - 87.