总之，再障患者T- bet mRNA 表达增高，呈现Th1细胞异常优势应答状态，说明Th1 细胞反应是再障的一个重要特征，并且可能是再障发生发展的关键。有学者提出可作为一种特异性调控Th0 分化、起Thl/Th2 转换开关作用的转录因子T- bet 可作为自身免疫性疾病的一个治疗靶点[15]。通过对再障患者T- bet 表达水平的研究，有助于我们进一步理解再障的发病机制，并有可能为再障临床诊断和治疗提供新策略。
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来源：浙江医学 作者：邢朝琴 黄强
