高血压患者颈动脉内中膜厚度与血清C-反应蛋白的相关性研究

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本研究在控制其他危险因素及排除高血压严重并发症的干扰后,发现高血压组CRP浓度显著高于正常对照组,随血压水平的升高CRP浓度也升高,CRP浓度与收缩压及舒张压呈正相关,提示CRP浓度可相应反映血压患者血压水平; 高血压组患者IMT显著大于正常对照组, CRP浓度与IMT呈正相关, IMT较厚患者CRP浓度增高,差异有显著性,这说明高血压患者血液中CRP浓度增高与颈动脉损伤、粥样硬化关系密切,因而在除外其他炎症反应的情况下,血清CRP的水平可间接反映颈动脉粥样硬化的程度。

综上所述,高血压患者血清C-反应蛋白水平增高与颈动脉内中膜厚度关系密切; C-反应蛋白水平随着高血压级别增大有增高的趋势,因而在除外其他炎症反应的情况下,血清C-反应蛋白的水平可间接反映颈动脉粥样硬化的程度,炎症反应可能参与了高血压病的发生、发展;降低C-反应蛋白浓度,抑制炎症反应可能阻止动脉粥样硬化的进展。

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来源：泰山医学院学报作者：宋志清,郭文,牛庆芹