参考文献:
[1 ]Huggins CB , Hodges CV. The effect of castration , of estrogen and of an2drogen injections on serum phosphatases in metastatic carcinoma of theprostate[J ] . Cancer Res ,1941 ,1(1) :293.
[2 ]Weber MJ , Gioeli D. Ras signaling in prostate cancer progression[J ] . JCell Biochem,2004 ,91 (1) :13.
[3 ]Chen CD , Welsbie DS , Tran C , et al . Molecular determinants of resis2tance to antiandrogen therapy[J ] . Nat Med ,2004 ,10 (1) :33.
[4 ]Gregory CW, Johnson RT , Mohler JL , et al . Androgen receptor stabiliza2tion in recurrent prostate cancer is associated with hypersensitivity to lowandrogen[J ] . Cancer Res ,2001 ,61 (7) :2892.
[5 ]Edwards J , Krishna NS , Grigor KM, et al . Androgen receptor gene am2plification and protein expression in hormone refractory prostate cancer[J ] . Br J Cancer , 2003 ,89 (3) :552.
[6 ]Holzbeierlein J , Lal P , LaTulippe E , et al . Gene expression analysis ofhuman prostate carcinoma during hormonal therapy identifies androgen -responsive genes and mechanisms of therapy resistance[J ] . Am J Pathol ,2004 ,164 (1) :217.
[7 ]Taplin ME , Balk SP. Androgen receptor : a key molecule in the progres2sion of prostate cancer to hormone independence [ J ] . J Cell Biochem,2004 ,91 (3) :483.
[8 ]Taplin ME , Rajeshkumar B , Halabi S , et al . Androgen receptor muta2tions in androgen - independent prostate cancer : Cancer and LeukemiaGroup B Study 9663[J ] . J Clin Oncol ,2003 ,21(14) :2673.
[9 ]LF Lee , MC Louie , SJ Desai ,et al . Interleukin - 8 confers androgen -independent growth and migration of LNCaP : differential effects of tyro2sine kinases Src and FAK[J ] . Oncogene ,2004 ,23 (12) :2197.
[10 ]Culig Z , Steiner H , Bartsch G, et al . Interleukin - 6 regulation ofprostate cancer cell growth[J ] . J Cell Biochem,2005 ,95 (3) :497.
[11 ]Lauren Wallner , Jinlu Dai , June Escara - Wilke. et al . Inhibition of In2terleukin - 6 with CNTO328 , an Anti - Interleukin - 6 Monoclonal Anti2body , Inhibits Conversion of Androgen - Dependent Prostate Cancer toan Androgen - Independent Phenotype in Orchiectomized Mice[J ] . Can2cer Research ,2006 ,66 (6) :3087.
[12 ]Scott M. Dehm, Kevin M. Regan , Lucy J . Schmidt ,et al . SelectiveRole of an NH2 - Terminal WxxLF Motif for Aberrant Androgen Recep2tor Activation in Androgen Depletion - Independent Prostate CancerCells[J ] . Cancer Research ,2007 ,67 (20) :10067.
[13 ]Pienta KJ , Loberg R. The ”emigration , migration , and immigration”ofprostate cancer[J ] . Clin Prostate Cancer ,2005 ,4(1) :24.
[14 ] Wang L , Hsu CL , Chang C. Androgen receptor corepressors : anoverview[J ] . Prostate ,2005 ,63(2) :117.
[ 15 ]Comuzzi B , Lambrinidis L , Rogatsch H , et al . The transcriptional co -activator cAMP response element - binding protein - binding protein isexpressed in prostate cancer and enhances androgen - and anti - andro2gen - induced androgen receptor function [J ] . Am J Pathol ,2003 ,162(1) :233.
[16 ]Ta - Chun Yuan , Suresh Veeram,aniMing - Fong Lin ,et al . Neuroen2docrine - like prostate cancer cells : neuroendocrine transdifferentiationof prostate adenocarcinoma cells[J ] . Endocrine - Related Cancer ,2007 ,14 (3) :531.
[17 ]Grande M,Carlstrom K,Rozell BL ,et al . Tissue concentrations of tissuepolypeptide antigen(TPA) and prostatic specific antigen(PSA) in 42 pa2tients with prostatic carcinoma[J ] . Prostate ,2000 ,45 (4) :299.
[18 ]Cluetjens CBJM,Steketee K,van Eekelen CCEM,at al . Both androgenreceptor and gllucocorticoid receptor are able to induce prostate - specif2ic antigen expreesion ,but differ in their growth stimulating properties ofLNCaP cell [J ] . Endocrinology ,1997 ,138 (12) :5293.
[19 ]Devon A , Lawson ,Owen N. Witte ,et al . Stem cell in prostate cancerinitiation and progression[J ] . J . Clin. Invest ,2007 ,117(18) :2044.
[20 ]Collins AT , Berry PA , Hyde C , et al . Prospective identification of tu2morigenic prostate cancer stem cells [J ] . Cancer Res , 2005 , 65 (23) :10946.
[21 ]O’Donnell A , Judson I , Dowsett M, et al . Hormonal impact of the 17- hydroxylase/ C ( 17 , 20 ) - lyase inhibitor abiraterone acetate(CB7630) in patients with prostate cancer [J ] . Br J Cancer ,2004 ,90(12) :2317.
[22 ]Adam Schayowitz , Gauri Sabnis , Vincent C. O. Njar . et al . Synergisticeffect of a novel antiandrogen , VN/ 124 - 1 , and signal transduction in2hibitors in prostate cancer progression to hormone independence in vitro[J ] . Molecular Cancer Therapeutics ,2008 ,7 (1) :121.