参考文献

[ 1 ] 　Dorins B, Paola P, et al. Matrixmetallop roteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor(VEGF) by ovarian carcinoma cells[ J ]. Cancer Res, 2003, 63:522425229.

[ 2 ] 　Geva E, Jaffe RB. Role of vascular, cendothelial growth factor in o2varian physiologyand pathology[ J ]. Fertil Steril, 2000, 74: 4292443.

[ 3 ] 　Sartori S, Nielsen I, TassinariD, et al. Evaluation of a standard2ized p rotocol of intracavitary recombinant interferon alpha22b inthe palliative treatment of malignant peritoneal effusions. A p ro2spective p ilot study[ J ]. Oncology, 2001, 61 (3) : 1922196.

[ 4 ] 　Stuart GC, Nation JG, SniderDD, et al. Intraperitoneal interfer2on in the management ofmalignant ascites[ J ]. Cancer, 1993, 71(6) : 202722030.

[ 5 ] 　Muc2Wierzgon M,Madej K. Intraperitoneal use of human tumornecrosis factor ( hrTNFalfa) in patients with ascites during ad2vanced neop lastic disease [ J ]. Pol Arch Med Wewn, 1996, 95(4) : 3572361.

[ 6 ] 　Xu L, Yoneda J, Herrera C, et al. Inhibition ofmalignant asci2tes and growth of human ovarian carcinoma by oral administrationof a potent inhibitor of the vascular endothelial growth factor re2cep tor tyrosine kinases[ J ]. Int J Oncol, 2000, 16 (3) : 4452454.

[ 7 ] 　Hasumi Y,MizukaHmi H,UrabeM, et al. Soluble FLT21 exp res2sion supp resses carcinomatous ascites in nude mice bearing ovari2an cancer[ J ]. Cancer Res, 2002, 62 (7) : 201922023.

[ 8 ] 　Verheul HM, Hoekman K, Jorna AS, et al. Targeting vascularendothelial growth factor blockade: ascites and p leural effusionformation[ J ]. Oncologist, 2000, 5 ( supp l1) : 45250.

[ 9 ] 　Beattie GJ, Smyth JF. Phase I study of intraperitonealmetallop ro2teinase inhibitor BB94 in patients with malignant ascites [ J ].Clin Cancer Res, 1998, 4 (8) : 189921902.

[ 10 ] 　Macaulay VM, O′Byrne KJ, SaundersMP, et al. Phase I studyof intrap leural batimastat (BB294 ) , a matrix metallop roteinaseinhibitor, in the treatment of malignant p leural effusions [ J ].Clin Cancer Res, 1999, 10 (3) : 5132520.

[ 11 ] 　Low JA, JohnsonMD, Bone EA, et al. The matrixmetallop rotei2nase inhibitor batimastat (BB294 ) retards human breast cancersolid tumor growth but not ascites formation in nude mice [ J ].Clin Cancer Res, 1996, 2 (7) : 120721214.

[ 12 ] 　KuglerA, Stuhler G, Walden P, et al. Regression of human me2tastatic renal cell carcinoma after vaccination with tumor cell2dendritic cell hybrids[ J ]. NatureMed, 2000, 6: 3322336.

[ 13 ] 　Huang L, Ohno T. Protective antitumor immunity induced byfixed tumor cells in combination with adjuvant in a murine hepa2tomamodel[ J ]. Cancer Lett, 2003, 202: 1532159.

[ 14 ] 　Schwaab T, Tretter CP, Gibson JJ, et al. Immunological effectsof granulocyte2macrophage colony2stimulating factor and autolo2goustumor vaccine in patients with renal cell carcinoma [ J ]. U2rology, 2004, 171 (3) : 103621042.

[ 15 ] 　何永文. 肿瘤热疗相关研究进展[ J ]. 国外医学口腔医学分册, 2000, 27 (1) : 14217.

[ 16 ] 　吕国荣,李新丰. 高频电流肿瘤热疗仪[ J ]. 医疗装备, 1999,12 (6) : 425.

[ 17 ] 　赵彼得,郭新娜. 高频透热治癌[M ]. 北京:人民军医出版社.1993: 1253.