参考文献:
〔1〕Valverde AM, Burks DJ, Fabregat I, et al. Molecular mechanisms of insulinresistance in IRS- 2- deficient hepatocytes〔J〕. Diabetes , 2003,9:2239- 2248.
〔2〕Hirata AE, Alvarez- Rojas F, Carvalheira JB, et al. Modulation of IR/PTP1B interaction and downstreamsignaling in insulin sensitive tissuesofMSG- rats. 〔J〕.LifeSci ,2003,8:1369- 1381.
〔3〕GumRJ, Gaede LL, SandraL. Reduction of protein tyrosine phosphatase1B increases insulin- dependent signaling in ob/ob mice 〔J〕.Diabetes2003, 1:21- 28
〔4〕Stiles B, Wang Y, Stahl A. Live- specific deletion of negative regulatorPten results in fatty liver and insulin hypersensitivity〔J〕. Proc Natl AcadSci USA ,2004,2:2082- 2087.
〔5〕Cline GW, Johnson K, Regittnig W, et al. Effects of a novel glycogensynthase kinase- 3 inhibitor on insulin- stimulated glucose metabolismin Zucker diabetic fa/fa) rats 〔J〕. Diabetes , 2002,10:2903- 2910.
〔6〕Sun Y, Liu S, Ferguson S, et al. Phosphoenolpyruvate carboxykinaseoverexpression selectively attenuates insulin signaling and hepatic insulinsensitivity in transgenic mice 〔J〕. Biol Chem, 2002,6:23301 -23307.
〔7〕Yamauchi T, Kamon J, Minokoshi Y. Adiponectin stimulates glucose utilizationand fatty- acid oxidation by activating AMP- activated proteinkinase〔J〕. Nat Med 2002,11:1288- 1295.
〔8〕Maeda N, Funahashi T. Adiponectin knockout mice 〔J〕.Nippon Rinsho2004,6:1067- 1076.
〔9〕KimYB, Uotani S, Pierroz DD, et al. In vivo administration of leptin activatessignal transduction directlyin insulin sensitive tissues: overlappingbut distinct pathwaysfrom insulin 〔J〕. Endocrinology ,2000,7:2328- 2339.
〔10〕Suzuki R, Tobe K, Aoyama M, et al. Both insulin signaling defects inthe liver andobesity contribute to insulin resistance and cause diabetesin Irs2- /- mice〔J〕.Biol Chem,2004,6:25039- 25049.
〔11〕Ye JM, Iglesias MA, Watson DG, et al. PPARa/a ragaglitazar eliminatesfatty liver and enhancesinsulin action in fat2 fed rats in the absenceof hepatomegaly. 〔J〕.Physiol Endocrinol Metab ,2003,3:531 -540.
〔12〕Daitoku H, Yamagata K, Matsuzaki H,et al. Regulation of PGC- 1 promoteractivity by protein kinase Band the forkhead transcription factorFKHR〔J〕. Diabetes,2003,3:642- 649.
〔13〕Alick G ,Sprangers F,Weverling GJ, et al .Free fatty acids increase hepaticglycogen content in obese males. 〔J〕.Metabolism, 2004,53:886-893.
〔14〕Roden M, Stingl H, Chandramouli V. et al. Effects of free fatty acidelevation on postabsorptive endogenous glucose production and gluconeogenesisin humans〔J〕.Diabetes,2000,49:701- 707.
〔15〕Song S,Andrinkopoulos S,Filippis C,et al. Mechanism of fat - inducedhepatic gluconeogenesis:effect of metformin 〔J〕.Physiol EndocrinolMetab, 2001,281:E275- 282.
〔16〕Kabir M, Catalano KJ,Ananthnarayan S ,et al. Molecular evidence supportingthe portal theory :a causative link between visceral adiposityand hepatic insulin resistance 〔J〕. Physiol Endocrinol Metab,2005,288: 454- 461.
〔17〕Hoppener WM, Ahem B, Lips CJ, et al. Islet amyloid and type 2 diabetesmellitus〔J〕. NewEngMed, 2000, 343: 41 1- 419。
〔18〕Gebre Medhin S, Olefssen C, Mulder H. Is1et amyloid polypeptide inthe islets ef langerhans: friend or foe? 〔J〕. Diabetelegia, 2000, 43:687- 695.
〔19〕Ji -Ming Y E, Lim- Fraser M, Cooney G J et al. Evidence that amylinstimulates lipolysis in vivo: a possible mediator of induced insulin resistance〔J〕. AmJ Physio1,2001,280: 562- E569.
〔20〕Owen SK. Amylin replacement therapy in patients with insulin - requiringtype 2 diabetes〔J〕.Diabetes Educ., 2006 , 3:105 - 110.
