非酒精性脂肪肝的研究进展

www.yongyao.net　　2009-9-4 13:53:55　　来源：　　责任编辑：

分享到：

参考文献
[ 1 ] Brunt EM. Nonalcoholic steatohepatitis[ J ]. Semin Liver Dis, 2004, 24(1) : 3220.
[ 2 ] AssyN, Kaita K, Mymin D, et al. Fatty infiltration of liver in hyperlip idemic patients[ J ]. Dig Dis Sci, 2000, 45 (10) : 192921934.
[ 3 ] Clark JM, Brancati FL, Diehl AM. Nonalcoholic fatty liver disease[ J ]. Gastroerterology, 2002, 122 (6) : 164921657.
[ 4 ] Angulo P. Nonalcoholic fatty liver disease[ J ]. N Engl JMed, 2002, 346(16) : 122121231.
[ 5 ] 范建高. 酒精性脂肪肝的临床流行病学研究[ J ]. 中华消化杂志,2002, 22 (2) : 1062107.
[ 6 ] Marchesini G, BriziM, Bianchi G, et al. Nonalcoholic fatter liver disease: a feature of the metabolic syndrome[ J ]. Diabetes, 2001, 50 ( 8) :184421850.
[ 7 ] Zamora2Valdes D, Chavez2Tap ia NC, Mendez2Sanchez N. Molecular mechanisms of insulin resistance [ J ]. Med Sur, 2004, 11 ( 3 ) :1492159.
[ 8 ] Liu YF, HerschkovitzA, Boura2Halfon S, et al. Serine phosphorylationp roximal to its phosphotyrosine binding domain inhibits insulin recep torsubstrate 1 function and p romotes insulin resistance[ J ]. Mol CellBiol,2004, 24 (21) : 966829681.
[ 9 ] Donnelly KL, Smith CI, Schwarzenberg SJ, et al. Sources of fatty acids stored in liver and secreted via lipop roteins in patientswith nonalcoholicfatty liver disease[ J ]. J Clin Invest, 2005, 115 (5) : 134321351.
[ 10 ] Barazzoni R, BosuttiA, StebelM, et al. Ghrelin regulatesmitochondrial2lip id metabolism gene exp ression and tissue fat distribution in liver and skeletal muscle [ J ]. Am J Physiol EndocrinolMetab, 2005,288 (1) : E2282235.
[ 11 ] Xu A, Wang Y, Keshaw H, et al. The fat2derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice[ J ]. J Clin Invest, 2003, 112 (1) : 912100.
[ 12 ] Chen G, Liang G, Ou J, et al. Central role for liver X recep tor in insulin2mediated activation of Srebp21c transcrip tion and stimulation of fatty acid synthesis in liver[ J ]. Proc Natl Acad Sci USA, 2004, 101(31) : 11245211250.
[ 13 ] Shimomura I, Bashmakov Y, Horton JD. Increased levels of nuclear SREBP21c associated with fatty livers in two mouse models of diabetes mellitus[ J ]. J Biol Chem, 1999, 274 (42) :30028230032.
[ 14 ] Considine RV, SinhaMK, HeimanML, et al. Srum immunoreaetive leptin concentrations in normal weight and obese humans [ J ]. N Engl JMed, 1996, 334 (5) : 2922295.
[ 15 ] Kap lan LM. Lep tin, obesity, and liver disease [ J ]. Gastroenterology,1998, 115 (4) : 99721001.
[ 16 ] KojimaM, hoseda H, Date Y, et al. Ghrelinis a growth2hormone2releasing a cylated pep tide from stomach [ J ]. Nature, 1999, 402 ( 6762) :6562660.
[ 17 ] lkezaki A, Hoseda H, Tto K, et al. Fasting p lasma ghrelin levels are negatively correlated with insulin resistance and PAT21, but not withlep tin, in obese children and adoscents[ J ]. Diabetes, 2002, 51 ( 12) :340823411.
[ 18 ] Aeakawa A, Inui A, kaga T, et al. Antogonism of ghrelin recep tor reduce food intake and bodyweight gain in mice[ J ]. Gut, 2003, 52 (7) :9472952.
[ 19 ] Fu Y, Luo N, Klein RL, et al. Adiponectin p romotes adipocyte differentiation, insulin sensitivity, and lip id accumulation[ J ]. J Lip id Res,2005, 46 (7) : 136921379.
[ 20 ] Bugianesi E, Pagotto U, Manini R, et al. Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepaticfat content, not to liver disease severity [ J ]. J Clin EndocrinolMetab, 2005, 90 (6) : 349823504.
[ 21 ]Mendez2Sanchez N, Chavez2Tap ia NC, Zamora2Valdes D, et al. Adiponectin, structure, function and pathophysiological imp lications innonalcoholic fatty liver disease [ J ]. Mini Rev Med Chem, 2006, 6(6) : 6512656.
[ 22 ] 曾民德. 葡萄糖毒性、脂肪毒性与非酒精性脂肪肝病[ J ]. 中华肝脏病杂志, 2005, 13 (2) : 81282
[ 23 ] PanM, Cederbaum A I, Zhang YL, et al. Lip id peroxidation and oxidant stress regulate hepatic apolipop rotein B degradation and VLDLp roduction[ J ]. J Clin Invest, 2004, 113 (9) : 127721287.
[ 24 ] 范竹萍,邱德凯,谢渭芬,等. 肥胖伴非酒精性脂肪性肝病的临床研究[ J ]. 肝脏, 2004, 9 (3) : 1552158.
[ 25 ] Woodcroft KJ, HafnerMS,Novak RF. Insulin signaling in the transcriptional and posttranscrip tional regulation of CYP2E1 exp ression [ J ].Hepatology, 2002, 35 (2) : 2632273.
[ 26 ] Schattenberg JM, Wang Y, Singh R, et al. Hepatocyte CYP2E1 overexp ression and steatohepatitis lead to impaired hepatic insulin signaling[ J ]. J Biol Chem, 2005, 280 (11) : 988729894.
[ 27 ] MaqanaMM,Osborne TF. Two tandem binding sites for sterol regulatory of fatty acid synthase p romotter[ J ]. J Biol Chem, l996, 27 l ( 51) :32689232694.
[ 28 ] Neuschwander2Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis:summary of an AASLD Single Top ic Conference [ J ]. Hepatology,2003, 37 (5) : 120221219.
[ 29 ] Yeon JE, Choi KM, Baik SH, et al. Reduced exp ression of peroxisome p roliferator2activated recep tor2alpha may have an important rolein the development of non2alcoholic fatty liver disease[ J ]. J Gastroenterol Hepatol, 2004, 19 (7) : 7992804.
[ 30 ] Mofrad P, ContosMJ, HaqueM, et al. Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values[ J ]. Hepatology, 2003, 37 (6) : 128621292 .
[ 31 ] Poordad FF. Therapeutic strategies in nonalcoholic fatty liver disorders[ J ]. Expert Op in Emerg Drugs, 2005, 10 (2) : 2372239.
[ 32 ] Buqianesi E, Gentilcore E,Manini R, et al. A randomized controlled trial ofmetformin versus vitamin E or p rescrip tive diet in nonalcoholicfatty liver disease[ J ]. Am J Gastroenterol, 2005, 100 (5) : 108221090.
[ 33 ] Li Z, Yang S,Lin H, et al. Probiotics and antibodies to TNF inhibit inflammatory activity and imp rove nonalcoholic fatty liver disease [ J ].Hepatology, 2003, 37 (2) : 3432350.
[ 34 ] Xu A,Wang Y, Keshaw H, et al. The fat2derived hormone adiponectinalleviated alcoholic and non2alcoholic fatty liver disease in mice [ J ].J Clin Invest, 2003, 112 (1) : 912100.