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支气管哮喘的糖皮质激素治疗机制及研究进展
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参考文献
1 Wu B , Li P ,Liu Y,et al. 3D structure of human FK506 - binding protein 52 : implications for the assembly of the glucocorticoid receptor/ Hsp90/ immunophilin heterocomplex. Proc Natl Acad
Sci USA ,2004 ,101 :834828353.
2 Dostert A , Heinzel T. Negative glucocorticoid receptor response elements and their role in glucocorticoid action. Curr Pharm Des ,2004 ,10 :280722816.
3 Ito K,Barnes PJ ,Adcock IM. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits IL21β2induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol ,2000 ,20 :689126903.
4 Roth SY,Denu JM ,Allis CD. Histone acetyltransferases. AnnuRev Biochem ,2001 ,70 :812120.
5 Privalsky ML. The role of corepressors in transcriptional regulation by nuclear hormone receptors. Annu Rev Physiol ,2004 ,66 :3152360.
6 Mittelstadt PR ,Ashwell JD. Inhibition of AP21 by the glucocorticoid2inducible protein GILZ. J Biol Chem , 2001 , 276 : 2960329610.
7 Kagoshima M , Wilcke T , Ito K, et al. Glucocorticoid2mediated transrepression is regulated by histone acetylation and DNA methylation. Eur J Pharmacol ,2001 ,429 :3272334.
8 Clark AR. MAP kinase phosphatase 1 :a novel mediator of biological effects of glucocorticoids ? J Endocrinol ,2003 ,178 :5212.
9 Engelbrecht Y, de Wet H , Horsch K,et al. Hulley , Glucocorticoids induce rapid up2regulation of mitogen2activated protein kinase phosphatase21 and dephosphorylation of extracellular signalregulated kinase and impair proliferation in human and mouse osteoblast cell lines. Endocrinology ,2003 ,144 :4122422.
10 Hall SE , Lim S , Witherden IR , et al. Lung type Ⅱ cell and macrophage annexin Ⅰ release : differential effects of two glucocorticoids. Am J Physiol ,1999 ,276 :L1142L121.
11 Anderson P ,Phillips K,Stoecklin G,et al. Post2transcriptional regulation of proinflammatory proteins. J Leukoc Biol ,2004 ,76 : 4247.
12 Beckett PA , Howarth PH. Pharmaco therapy and airway remodelling in asthma ? Thorax ,2003 ,58 (2) :1632174.
13 Dorscheid DR ,Wojcik KR ,Sun S ,et al. Apoptosis of airway epithelial cells induced by corticosteroids. Am J Respir Crit CareMed ,2001 ,164 (10 Pt 1) :193921947.
14 邵亚娟,高金明,林耀广. 白介素217 在支气管哮喘气道炎症发病机制中的作用. 国外医学呼吸系统分册,1999 ,23 (2) :87.
15 Tang L K,Wilson JW, Stewart AG,et al. Airway remodelling in asthma : current understanding and implications for future therapies. Pharmacol Ther , 2006 ,112 (2) :4742488.
16 Hoshino M ,Nakamura Y,Sim J ,et al. Bronchial subepithelial fibrosis and expression of matrix metalloproteinase29 in asthmatic airway inflammation. J Allergy Clin Immunol , 1998 , 102 : 7832
788.
17 Benson SC ,Lu Valle PA1Inhibition of lysyl oxidase and prolyl hydroxylase activity in glucocorticoid treated rats. Biochem BiophysRes Commun ,1981 ,99 :5572562.
18 Goncharova EA ,Billington CK, Irani C ,et al. Cyclic AMP2mobilizing agents and glucocorticoids modulate human smooth musclecell migration. Am J Respir Cell Mol Biol ,2003 ,29 :19227.
19 Wignarajah D ,Zheng L , Harding R ,et al. Inhaled corticosteroids and VEGF concentrations in asthmatic bronchoalveolar lavage fluid. Thorax ,2003 ,58 Suppl 3 :15.
20 Lu W,Lillehoj EP ,Kim KC. Effects of dexamethasone on Mucoac mucin production by primary airway goblet cells. Am J Physiol Lung Cell Mol Physiol ,2005 ,288 :52260.

来源:山西医药杂志  作者:张静 杜永成 胡晓芸

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