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“无线粒体”原生寄生虫感染的治疗及其作用靶点
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[ 1 ] 何德,董玖红,文建凡,等. 几类“无线粒体”原生动物进化地位的探讨———来自DNA 拓扑异构酶Ⅱ的系统分析证据[ J ]. 中国科学C辑, 2005, 35 (2) : 115-122.
[ 2 ]  Marr J J , TimothyW N, RichardW K. M olecularM edicalParasitology [M ]. London:Elsevier Science L td, 20031
[ 3 ]  詹希美. 人体寄生虫学[M ]. 第5 版. 北京:人民卫生出版社, 2001: 611
[ 4 ]  Higber D A. Sexual transmission of giardiasis [ J ]. AmFam Physician, 1997, 55 (2) : 442-444.
[ 5 ]  AdamR D. Biology of Giardia lam blia [ J ]. Clin M icrobiolRev, 2001, 14 (3) : 447-475.
[ 6 ]  Sadaga G A, Kassem H H. Prevalence of intestinal parasites among p rimary schoolchildren in Derna District,L ibya[ J ]. J Egypt Soc Parasitol, 2007, 37 (1) : 205-2141
[ 7 ]  RutkowskiM R, Harmsen A G. Tritrichom onas foetus:pathogenesis of acute infection in normal, estradiol2treated, and stressed mice[ J ]. Exp Parasitol, 2007, 115 (2) :143-159.
[ 8 ]  Brown D M,Upcroft J A,Upcroft P. Cysteine is the majorlow2molecularweight thiol in Giardia duodenalis [ J ]. M olB iochem Parasitol, 1993, 61 (1) : 156-158.
[ 9 ]  Calzada F, Cervantes2Martínez J A, Yépez2Mulia L. Invitro antip rotozoal activity from the roots of Geranium mexicanum and its constituents on Entam oeba histoly ticaand Giardia lam blia [ J ]. J Ethnopharm acol, 2005, 98 ( 122) : 191-193.
[ 10 ] Hansen W R, Tulyathan O, Dawson S C, et al. Giardialam blia attachment force is insensitive to surface treatments[ J ]. Eukaryot Cell, 2006, 5 (4) : 781-783.
[ 11 ] Gosling P J. D ictionary of Parasitology [M ]. Boca Raton:Taylor & Francis Group, 2005: 161
[ 12 ] Gillesp ie S H, Pearson R D. Principles and Practiceof Clinical Parasitology [M ]. Chichester: JohnWiley & SonsLtd, 20011
[ 13 ] Embley TM,MartinW. Eukaryotic evolution, changes and challenges[ J ]. N ature, 2006, 440 (7084) : 623-630.
[ 14 ] Keeling P J ,Burger G,Durnford D G, et al. The tree of eukaryotes[ J ]. Trends Ecol Evol, 2005, 20 (12) : 670-676.
[ 15 ] Tovar J , Leon2Avila G, Sanchez L B, et al. Mitochondrial remnant organelles of Giardia function in iron2sulphurp rotein maturation [ J ]. N ature, 2003, 426 ( 6963 ) :172-176.
[ 16 ] Vahab A, Tomoyoshi N. Current therapeutics, their p roblems, and sulfur2containing2amino2acid metabolism as anovel target against infections by“amitochondriate”protozoan parasites [ J ]. Clin M icrobiol Rev, 2007, 20 ( 1 ) :164-187.
[ 17 ] Saavedra E,OlivosA, Encalada R, et al. Entam oeba histoly tica: kinetic and molecular evidence of a p reviously unidentified pyruvate kinase [ J ]. Exp Parasitol, 2004, 106(122) : 11-21.
[ 18 ] Pütz S, Gelius2Dietrich G, Piotrowski M, et al. Rubrerythrin and peroxiredoxin: two novel putative peroxidases in the hydrogenosomes of the microaerophilic p rotozoon Trichom onas vaginalis [ J ]. M ol B iochem Parasitol,2005, 142 (2) : 212-223.
[ 19 ] Vega2Robledo G B, Leandro E, Silva R, et al. Effect of zinc2treated Entam oeba histoly tica on the human polymorphonuclear resp iratory burst[ J ]. A rch M ed Res, 2005, 36(1) : 75-79.
[ 20 ] Nozaki T, Ali V, Tokoro M. Sulfur2containing amino acidmetabolism in parasitic p rotozoa [ J ]. Adv Parasitol,2005, 60: 12991
[ 21 ] OkadaM, Kobayashi K. Recent p rogress in mycobacteriology[ J ]. Kekkaku, 2007, 82 (10) : 783-799.
[ 22 ] Andersson J O, Hirt R P, Foster P G, et al. Evolution of four gene families with patchy phylogenetic distributions:influx of genes into p rotist genomes [ J /OL ]. BMC EvolB iol, 2006, 6: 27 [ 2007-12-18 ]. http: / /www. pubmedcentral. nih. gov/ articlerender. fcgi? tool =
pubmed&pubmedid = 16551352.
[ 23 ] Horner D S, Heil B, Happe T, et al. Iron hydrogenases—ancient enzymes in modern eukaryotes [ J ]. Trends B iochem Sci, 2002, 27 (3) : 148-153.
[ 24 ] Samuelson J. Why metronidazole is active against both bacteria and parasites[ J ]. Antim icrob Agents Chem other,1999, 43 (7) : 1533-1541.
[ 25 ] El2Kamel A H, Ashri L Y, Alsarra I A. Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases [ J /OL ]. AAPS Pharm Sci Tech, 2007, 8 (3) : E12E11 [ 2007-12-18 ]. http: / /www. aap spharmscitech. org/view. asp
art = p t08030751
[ 26 ] Nixon J E,Wang A, Field J , et al. Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases,NADH oxidase, and alcohol dehydrogenase 3 from anaerobic p rokaryotes to Giardia lam blia and Entam oeba histoly tica [ J ]. Eukaryot Cell, 2002, 1 (12) : 181-190.
[ 27 ] Dunn L A,Andrews K T,McCarthy J S, et al. The activity of p rotease inhibitors against Giardia duodenalis and metronidazole2resistant Trichom onas vaginalis[ J ]. Int J Antim icrob Agents, 2007, 29 (1) : 98-102.
[ 28 ] Schwebke J R, Barrientes F J. Prevalence of Trichom onasvaginalis isolates with resistance to metronidazole and tinidazole [ J ]. Antim icrob Agents Chem other, 2006, 50
(12) : 4209-4210.
[ 29 ] Brady R L, Cameron A. Structure2based app roaches to the development of novel anti2malarials [ J ]. Curr D rug Tar2gets, 2004, 5 (2) : 137-149.
[ 30 ] Buckner, F S, Eastman R T, Yokoyama K, et al. Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis [ J ]. Curr Opin InvestigD rugs, 2005, 6 (8) : 791-797.
[ 31 ] Croft, S L, BarrettM P, Urbina J A. Chemotherapy of trypanosomiases and leishmaniasis[ J ]. Trends Parasitol,2005, 21 (11) : 508-512.
[ 32 ] Hinchliffe P, Sazanov L A. Organization of iron2sulfur clusters in resp iratory comp lex I[ J ]. Science, 2005, 309(5735) : 771-774.
[ 33 ] Morrison H G,McArthur A G, Gillin F D, et al. Genomic minimalism in the early diverging intestinal parasite Giardia lam blia [ J ]. Science, 2007, 317 (5846) : 1921-1926.
[ 34 ] AliV, Shigeta Y, Tokumoto U, et al. An intestinal parasitic p rotist, Entam oeba histoly tica, possesses a non2redundant nitrogen fixation2like system for iron2sulfur cluster assembly under anaerobic conditions [ J ]. J B iol Chem ,2004, 279 (16) : 16863-16874.
[ 35 ] Outten FW,Djaman O, Storz G. A suf operon requirement for Fe2S cluster assembly during iron starvation in Escherichia coli[ J ]. M olM icrobiol, 2004, 52 (3) : 861-872.
[ 36 ] McKie A E, Edlind T,Walker J , et al. The p rimitive p rotozoon Trichomonas vaginalis contains two methionine gamma2lyase genes that encode members of the gamma2family of pyridoxal25′2 phosphate2dependent enzymes [ J ]. J B iolChem, 1998, 273 (10) : 5549-5556.
[ 37 ] Tokoro M, Asai T, Kobayashi S, et al. Identification and characterization of two isoenzymes ofmethionine gammalyase from Entam oeba histolytica: a key enzyme of sulfuramino acid degradation in an anaerobic parasitic p rotist that lacks forward and reverse transsulfuration pathways[ J ]. J B iol Chem, 2003, 278 (43) : 42717-42727.
[ 38 ] Messerschmidt A,WorbsM, Steegborn C, et al. Determinants of enzymatic specificity in the Cys2Met2metabolism PLP2dependent enzymes family: crystal structure of cystathionine gamma2lyase from yeast and intrafamiliar structure comparison [ J ]. B iol Chem, 2003, 384 ( 3 ) :373-386.
[ 39 ] Hell R, Hillebrand H. Plant concep ts for mineral acquisition and allocation [ J ]. Curr Opin B iotechnol, 2001, 12(2) : 161-168.
[ 40 ] Balderas2Renteria I, García2Lázaro J F, Carranza2RosalesP, et al. Transcrip tional up regulation of genes related to virulence activation in Entam oeba histoly tica [ J ]. A rch
M ed Res, 2007, 38 (4) : 372-379.
[ 41 ] Westrop G D, Goodall G,Mottram J C, et al. Cysteine biosynthesis in Trichom onas vaginalis involves cysteine synthase utilizing O2phosphoserine [ J ]. J B iol Chem, 2006,
281 (35) : 25062-25075.
[ 42 ] Brosnan J T, Brosnan M E. The sulfur2containing amino acids: an overview [ J ]. J N utr, 2006, 136 ( 6 Supp l) :1636S-1640S.
[ 43 ] Yoshimura M, Nakano Y, Koga T. L2Methionine2gammalyase, as a target to inhibitmalodorous bacterial growth by trifluoromethionine [ J ]. B iochem B iophys Res Comm un,2002, 292 (4) : 964-968.
[ 44 ] Coombs G H,Mottram J C. Trifluoromethionine, a p rodrug designed against methionine gamma2lyase2containing pathogens, has efficacy in vitro and in vivo against Trichom onas vaginalis[ J ]. Antim icrob Agents Chem other,2001, 45 (6) : 1743-1745.
[ 45 ] Ikegami F,MizunoM, Kihara M, et al. Enzymatic synthesis of the thyrotoxic amino acid mimosine by cysteine synthase[ J ]. Phytochem istry, 1990, 29 (11) : 3461-3465.

来源:药学进展 作者:吴宇凡,郑珩

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